Raws li saturated ncaj saw aliphatic dibasic aldehyde, glutaraldehyde yog cov xim tsis muaj pob tshab uas muaj ntxhiab tsw thiab tua tau zoo heev ntawm cov kab mob ua me nyuam, kab mob, mycobacteria, kab mob pwm thiab kab mob kab mob, thiab tsis-oxidizing broad-spectrum bactericide.Glutaraldehyde yog cov tshuaj tua kab mob zoo heev uas tua tau ntau yam kab mob thiab tau pom zoo los ntawm World Health Organization ua cov tshuaj tua kab mob rau cov kab mob kab mob siab.
Glutaraldehyde 25%muaj stimulating thiab curing cuam tshuam rau tib neeg daim tawv nqaij thiab mucous daim nyias nyias thiab tej zaum yuav ua rau muaj kev tsis haum tshuaj, yog li nws yuav tsum tsis txhob siv tshuaj tua kab mob ntawm huab cua thiab cov tais diav.Tsis tas li ntawd, glutaraldehyde yuav tsum tsis txhob siv rau kev tua kab mob thiab ua kom tsis muaj menyuam ntawm cov khoom siv kho mob tubular, koob txhaj tshuaj, phais sutures thiab paj rwb xov.
Glutaraldehyde feem ntau yog siv los ua tshuaj tua kab mob hauv kev lag luam kho mob thiab cov neeg siv yuav muaj lus nug txog cov teeb meem kev lag luam, yog li Springchem ntawm no muaj cov ntsiab lus tseem ceeb txog glutaraldehyde rau koj siv.
AKev siv ntawm glutaraldehyde
Glutaraldehyde yog siv los ua cov tshuaj tua kab mob txias los tua cov khoom siv hluav taws xob, xws li endoscopes thiab cov cuab yeej lim ntshav.Nws yog siv los ua cov tshuaj tua kab mob siab rau cov cuab yeej phais uas tsis tuaj yeem ua kom tsis muaj cua sov.
Glutaraldehyde yog siv rau ntau daim ntawv thov hauv cov chaw kho mob:
● Ib cov ntaub so ntswg fixative nyob rau hauv pathology labs
● Tshuaj tua kab mob thiab ua kom tsis muaj menyuam ntawm qhov chaw thiab khoom siv
● Tus neeg sawv cev tawv tawv siv los tsim cov duab xoo hluav taws xob
● Rau kev npaj ntawm grafts
Kev tas sij hawmhnub tim ntawm glutaraldehyde thiab yuav ua li cas los txiav txim lub sij hawm
Nyob rau hauv chav tsev kub thiab nyob rau hauv cov xwm txheej ntawm nyob deb ntawm lub teeb thiab kaw cia, hnub tas sij hawm ntawm glutaraldehyde yuav tsum tsis txhob tsawg tshaj li 2 xyoo, thiab cov active ingredient cov ntsiab lus ntawm glutaraldehyde yuav tsum muaj tsawg kawg yog 2.0% nyob rau hauv lub hnub tas sij hawm.
Nyob rau hauv chav tsev kub, tom qab ntxiv xeb inhibitor thiab pH adjuster, glutaraldehyde yog siv rau kev kho mob immersion tshuaj tua kab mob los yog sterilization, thiab yuav siv tau rau 14 hnub tas mus li.Cov ntsiab lus glutaraldehyde yuav tsum yog tsawg kawg 1.8% thaum siv.
Kev nqhis dejdkab mobtxoj kevnrog glutaraldehyde
Soak cov cuab yeej ntxuav hauv 2.0% ~ 2.5% glutaraldehyde tshuaj tua kab mob kom submerge kom tiav, tom qab ntawd npog lub thawv tshuaj tua kab mob hauv chav sov li 60 min, thiab yaug nrog dej tsis muaj menyuam ua ntej siv.
Cov cuab yeej ntxuav thiab qhuav qhuav thiab kho cov cuab yeej, cov cuab yeej thiab cov khoom tau muab tso rau hauv 2% alkaline glutaraldehyde tov kom huv si, thiab cov npuas cua ntawm cov twj paj nruag yuav tsum tau muab tshem tawm nrog lub thawv ntim ntawm qhov kub ntawm 20 ~ 25 ℃.Cov tshuaj tua kab mob ua haujlwm kom txog rau thaum lub sijhawm teev cov lus qhia ntawm cov khoom.
Cov kev xav tau rau kev tua kab mob ntawm endoscopes nrog glutaraldehyde
1. Cov tshuaj tua kab mob siab thiab ua kom tsis muaj menyuam
● Concentration: ≥2% (alkaline)
● Sijhawm: bronchoscopy disinfection immersion lub sij hawm ≥ 20min;Lwm cov tshuaj tua kab mob endoscopes ≥ 10min;endoscopic immersion rau cov neeg mob uas muaj mycobacterium tuberculosis, lwm yam mycobacteria thiab lwm yam kab mob tshwj xeeb ≥ 45min;sterilization ≥ 10h
2. Siv txoj kev
● Endoscope ntxuav thiab tshuaj tua kab mob tshuab
● Kev khiav hauj lwm ntawm tes: cov tshuaj tua kab mob yuav tsum tau ntim nrog txhua lub yeeb nkab thiab tsau tshuaj tua kab mob
3. Ceev faj
Glutaraldehyde 25%yog allergenic thiab irritating rau ntawm daim tawv nqaij, qhov muag thiab ua tsis taus pa, thiab yuav ua rau dermatitis, conjunctivitis, qhov ntswg o thiab ua hauj lwm hawb pob, yog li nws yuav tsum tau siv nyob rau hauv endoscope tu thiab tshuaj tua kab mob tshuab.
Kev ceev faj nrog glutaraldehyde
Glutaraldehyde yog khaus rau ntawm daim tawv nqaij thiab mucous daim nyias nyias thiab lom rau tib neeg, thiab glutaraldehyde kua yuav ua rau mob loj rau lub qhov muag.Yog li ntawd, nws yuav tsum tau npaj thiab siv rau hauv qhov chaw uas muaj cua zoo, kev tiv thaiv tus kheej yuav tsum tau npaj kom zoo, xws li hnav lub npog ntsej muag, hnab looj tes tiv thaiv thiab tsom iav tiv thaiv.Yog tias tsis tuaj yeem tiv tauj, nws yuav tsum tau yaug tam sim ntawd thiab txuas ntxiv nrog dej, thiab kev kho mob ntxov yuav tsum tau nrhiav yog tias qhov muag raug mob.
Nws yuav tsum tau siv nyob rau hauv ib qho chaw zoo-ventilated, thiab yog tias tsim nyog, qhov chaw yuav tsum muaj cov khoom tso pa tawm.Yog hais tias qhov concentration ntawm glutaraldehyde nyob rau hauv cov huab cua ntawm qhov chaw ntawm kev siv yog siab dhau lawm, nws raug nquahu kom yuav tsum tau nruab nrog tus kheej-tso pa apparatus (zoo siab tiv thaiv daim npog qhov ncauj).Cov thawv uas siv rau cov twj tso kua mis yuav tsum huv si, npog thiab tua kab mob ua ntej siv.
Kev soj ntsuam ntau zaus ntawm glutaraldehyde concentration
Qhov zoo concentration ntawm glutaraldehyde tuaj yeem soj ntsuam nrog cov tshuaj ntsuam xyuas strips.
Nyob rau hauv tus txheej txheem ntawm kev siv tas mus li, kev saib xyuas txhua hnub yuav tsum tau ntxiv dag zog kom nkag siab nws cov kev hloov pauv, thiab nws yuav tsum tsis txhob siv thaum nws cov concentration pom hauv qab qhov xav tau concentration.
Nws yuav tsum tau ua kom ntseeg tau tias qhov concentration ntawm glutaraldehyde hauv kev siv ua tau raws li qhov yuav tsum tau ua ntawm phau ntawv qhia khoom.
Yuav tsumglutaraldehyde tau qhib ua ntej siv?
Cov tshuaj aqueous ntawm glutaraldehyde yog acidic thiab feem ntau tsis tuaj yeem tua cov kab mob hauv lub xeev acidic.Nws tsuas yog thaum cov tshuaj "activated" los ntawm alkalinity rau pH tus nqi ntawm 7.5-8.5 uas nws tuaj yeem tua cov spores.Thaum ua haujlwm, cov kev daws teeb meem no muaj lub neej txee ntev li 14 hnub.Ntawm alkaline pH, glutaraldehyde molecules zoo li polymerize.Lub polymerization ntawm glutaraldehyde tshwm sim nyob rau hauv lub kaw ntawm lub active site aldehyde pawg ntawm nws glutaraldehyde molecule lub luag hauj lwm rau tua budding spores, thiab yog li cov bactericidal nyhuv yog txo.
Cov xwm txheej cuam tshuam rau kev ua kom tsis muaj menyuam ntawm glutaraldehyde
1. Kev xav thiab lub sijhawm ua haujlwm
Cov nyhuv bactericidal yuav txhim kho nrog qhov nce ntawm concentration thiab txuas ntxiv ntawm lub sijhawm ua haujlwm.Txawm li cas los xij, glutaraldehyde tov nrog ib feem loj ntawm tsawg dua 2% tsis tuaj yeem ua tiav cov kab mob bactericidal txhim khu kev qha ntawm cov kab mob spores, txawm li cas los xij yuav txuas ntxiv lub sijhawm bactericidal.Yog li ntawd, nws yog ib qho tsim nyog yuav tsum siv glutaraldehyde tov nrog loj feem ntau dua 2% los tua cov kab mob spores.
2. Tshuaj acidity thiab alkalinity
Cov kab mob bactericidal ntawm cov kua qaub glutaraldehyde yog qhov qis dua li ntawm alkaline glutaraldehyde, tab sis qhov sib txawv yuav txo qis nrog qhov kub thiab txias.Hauv thaj tsam ntawm pH 4.0-9.0, cov nyhuv bactericidal nce nrog nce pH;qhov muaj zog bactericidal nyhuv yog pom ntawm pH 7.5-8.5;ntawm pH> 9, glutaraldehyde sai polymerizes thiab cov kab mob bactericidal poob sai.
3. Kub
Nws kuj muaj cov kab mob bactericidal ntawm qhov kub thiab txias.Cov kab mob bactericidal ntawm glutaraldehyde nce nrog qhov kub thiab txias, thiab nws qhov kub coefficient (Q10) yog 1.5 txog 4.0 ntawm 20-60 ℃.
4. Organic teeb meem
Organic teeb meem ua rau cov kab mob bactericidal tsis muaj zog, tab sis cov nyhuv ntawm cov organic teeb meem ntawm cov kab mob bactericidal ntawm glutaraldehyde yog me dua li ntawm lwm cov tshuaj tua kab mob.20% calf serum thiab 1% tag nrho cov ntshav tsis muaj kev cuam tshuam rau cov kab mob bactericidal ntawm 2% glutaraldehyde.
5. Synergistic nyhuv ntawm nonionic surfactants thiab lwm yam physicochemical yam
Polyoxyethylene fatty cawv ether yog ib qho nonionic surfactant, thiab kev ruaj ntseg thiab cov kab mob bactericidal tau zoo dua los ntawm kev ntxiv 0.25% polyoxyethylene fatty cawv ether rau glutaraldehyde tov formulated nrog enhanced acid-base glutaraldehyde.Ultrasound, deb infrared rays thiab glutaraldehyde muaj ib tug synergistic sterilization nyhuv.
Springchem, Tuam Tshoj sab saum toj 10 glutaraldehyde chaw tsim tshuaj paus, muab glutaraldehyde 25% thiab 50% rau kev lag luam, kuaj, kev ua liaj ua teb, kev kho mob, thiab qee lub hom phiaj hauv tsev, feem ntau rau kev tua kab mob thiab ua kom tsis muaj menyuam ntawm qhov chaw thiab khoom siv.Yog xav paub ntxiv, tsuas yog tiv tauj peb.
Post lub sij hawm: Aug-16-2022