Formaldehyde thiab glutaraldehydeyog ob qho tib si chemical agents siv los ua crosslinking agents hauv ntau daim ntawv thov, tshwj xeeb tshaj yog nyob rau hauv biology, chemistry, thiab cov ntaub ntawv science.Thaum lawv ua haujlwm zoo sib xws hauv crosslinking biomolecules thiab khaws cia cov qauv lom neeg, lawv muaj cov tshuaj lom neeg sib txawv, kev ua haujlwm, tshuaj lom, thiab kev siv.
Zoo sib xws:
Crosslinking Agents: Ob leeg formaldehyde thiabglutaraldehyde yog aldehydes, txhais tau tias lawv muaj ib pawg carbonyl (-CHO) thaum kawg ntawm lawv cov qauv molecular.Lawv lub luag haujlwm tseem ceeb yog tsim cov kev sib cog lus ntawm cov pab pawg ua haujlwm ntawm biomolecules, ua rau kev sib txuas.Crosslinking yog qhov tseem ceeb rau stabilizing cov qauv ntawm cov qauv lom neeg, ua rau lawv muaj zog dua thiab tiv taus degradation.
Biomedical Applications: Ob qho tib si formaldehyde thiab glutaraldehyde pom kev siv tseem ceeb hauv biomedical teb.Lawv feem ntau ua haujlwm rau cov ntaub so ntswg kho thiab khaws cia hauv kev tshawb fawb histology thiab pathology.Cov ntaub so ntswg crosslinked tswj lawv cov qauv kev ncaj ncees thiab tuaj yeem ua tiav ntxiv rau ntau lub hom phiaj kev tshuaj xyuas thiab tshuaj xyuas.
Microbial Control: Ob tus neeg sawv cev muaj cov khoom siv tshuaj tua kab mob, ua rau lawv muaj txiaj ntsig hauv kev tua kab mob thiab ua kom tsis muaj menyuam.Lawv tuaj yeem cuam tshuam cov kab mob, kab mob, thiab cov fungi, txo qhov kev pheej hmoo ntawm kev kis kab mob hauv chav kuaj thiab cov cuab yeej kho mob.
Daim ntawv thov kev lag luam: Ob qho tib si formaldehyde thiabglutaraldehydeyog siv nyob rau hauv ntau hom kev lag luam.Lawv ua hauj lwm nyob rau hauv zus tau tej cov adhesives, resins, thiab polymers, raws li zoo raws li nyob rau hauv tawv thiab textile kev lag luam.
Qhov txawv:
Chemical Structure: Qhov sib txawv ntawm formaldehyde thiab glutaraldehyde nyob hauv lawv cov qauv molecular.Formaldehyde (CH2O) yog qhov yooj yim tshaj plaws aldehyde, tsim los ntawm ib qho carbon atom, ob lub hydrogen atoms, thiab ib qho oxygen atom.Glutaraldehyde (C5H8O2), ntawm qhov tod tes, yog ib qho nyuaj aliphatic aldehyde, muaj tsib carbon atoms, yim hydrogen atoms, thiab ob atoms oxygen.
Reactivity: Glutaraldehyde feem ntau yog reactive dua formaldehyde vim nws cov roj carbon saw ntev.Lub xub ntiag ntawm tsib carbon atoms nyob rau hauv glutaraldehyde tso cai rau nws mus txuas ntxiv kev ncua deb ntawm cov pab pawg neeg ua hauj lwm ntawm biomolecules, ua rau kom ceev thiab ntau npaum crosslinking.
Crosslinking Efficiency: Vim nws cov reactivity ntau dua, glutaraldehyde feem ntau ua tau zoo ntawm crosslinking loj biomolecules, xws li cov proteins thiab enzymes.Formaldehyde, thaum tseem muaj peev xwm ntawm crosslinking, tej zaum yuav xav tau ntau lub sij hawm los yog ntau dua kom ua tiav cov txiaj ntsig sib piv nrog cov molecules loj.
Toxicity: Glutaraldehyde paub tias muaj tshuaj lom ntau dua li formaldehyde.Lub sij hawm ntev los yog tseem ceeb rau glutaraldehyde tuaj yeem ua rau tawv nqaij thiab ua pa ua pa, thiab nws raug suav tias yog ib qho sensitizer, txhais tau tias nws tuaj yeem ua rau muaj kev tsis haum rau qee tus neeg.Hauv qhov sib piv, formaldehyde yog cov kab mob carcinogen uas paub zoo thiab ua rau muaj kev phom sij rau kev noj qab haus huv, tshwj xeeb tshaj yog thaum nqus tau los yog sib cuag ntawm daim tawv nqaij.
Daim ntaub ntawv: Txawm hais tias ob qho tib si tshuaj siv rau hauv cov ntaub so ntswg kho, lawv feem ntau nyiam rau ntau lub hom phiaj.Formaldehyde feem ntau yog siv rau niaj hnub histological daim ntaub ntawv thiab embalming, thaum glutaraldehyde yog ntau haum rau khaws cia cellular qauv thiab antigenic qhov chaw nyob rau hauv electron microscopy thiab immunohistochemical kev tshawb fawb.
Kev ruaj ntseg: formaldehyde yog ntau volatile thiab nyhav evaporate sai dua glutaraldehyde.Cov cuab yeej no tuaj yeem cuam tshuam rau kev tuav thiab khaws cia ntawm cov neeg ua haujlwm sib txuas.
Hauv cov ntsiab lus, formaldehyde thiab glutaraldehyde sib koom cov yam ntxwv zoo li cov neeg ua haujlwm sib txuas, tab sis lawv txawv heev hauv lawv cov qauv tshuaj, kev ua haujlwm, tshuaj lom, thiab kev siv.Kev nkag siab zoo ntawm qhov sib txawv no yog qhov tseem ceeb rau kev xaiv tus neeg sawv cev crosslinking tsim nyog rau lub hom phiaj tshwj xeeb thiab ua kom muaj kev nyab xeeb thiab siv tau zoo hauv ntau yam kev tshawb fawb, kev kho mob, thiab kev lag luam.
Post lub sij hawm: Lub Xya hli ntuj-28-2023