Nws ib zaug hu ua "kub dawb", thiab nws lub koob npe nrov nyob rau hauv nws cov nyhuv dawb uas tsis sib piv tau ntawm ib sab tes, thiab qhov nyuaj thiab tsis txaus ntawm nws cov extraction ntawm qhov tod tes. Cov nroj tsuag Glycyrrhiza glabra yog qhov chaw ntawm Glabridin, tab sis Glabridin tsuas yog suav rau 0.1% -0.3% ntawm nws cov ntsiab lus tag nrho, uas yog hais tias, 1000kg ntawm Glycyrrhiza glabra tsuas yog tuaj yeem tau txais 100g ntawmGlabridin, 1g ntawm Glabridin yog sib npaug rau 1g ntawm lub cev kub.
Hikarigandine yog tus sawv cev ntawm cov khoom xyaw tshuaj ntsuab, thiab nws cov nyhuv dawb tau pom los ntawm Nyiv Pooj
Glycyrrhiza glabra yog ib tsob nroj ntawm genus Glycyrrhiza. Tuam Tshoj yog lub tebchaws uas muaj cov khoom siv tshuaj ntsuab nplua nuj tshaj plaws hauv ntiaj teb, thiab muaj ntau dua 500 hom tshuaj ntsuab siv hauv kev kho mob, ntawm cov uas siv ntau tshaj plaws yog licorice. Raws li cov ntaub ntawv txheeb cais, tus nqi siv ntawm licorice yog ntau dua 79%.
Vim yog keeb kwm ntev ntawm kev siv, nrog rau lub koob npe nrov, qhov kev tshawb fawb txog tus nqi ntawm licorice tsis yog tsuas yog tawg dhau qhov kev txwv ntawm thaj chaw xwb, tab sis kuj tau nthuav dav daim ntawv thov. Raws li kev tshawb fawb, cov neeg siv khoom hauv Es Xias, tshwj xeeb tshaj yog hauv Nyiv Pooj, muaj kev hwm heev rau cov tshuaj pleev ib ce uas muaj cov khoom xyaw nquag ntawm cov tshuaj ntsuab. 114 cov khoom xyaw tshuaj pleev ib ce tau raug sau tseg hauv "Nyiv Pooj Cov Khoom Siv Tshuaj Pleev Ib Ce Dav Dav", thiab twb muaj 200 hom tshuaj pleev ib ce uas muaj cov khoom xyaw tshuaj ntsuab hauv Nyiv Pooj.
Nws raug lees paub tias muaj cov nyhuv dawb super, tab sis qhov nyuaj hauv kev siv ua haujlwm yog dab tsi?
Qhov hydrophobic ntawm licorice extract muaj ntau yam flavonoids. Raws li lub ntsiab tivthaiv ntawm nws qhov hydrophobic, halo-glycyrrhizidine muaj cov teebmeem inhibitory rau melanin ntau lawm thiab kuj muaj cov teebmeem anti-inflammatory thiab anti oxidant.
Qee cov ntaub ntawv sim qhia tau hais tias qhov ua kom dawb ntawm lub teeb Glabridin yog 232 npaug ntau dua li cov vitamin C ib txwm muaj, 16 npaug ntau dua li hydroquinone, thiab 1,164 npaug ntau dua li arbutin. Yuav ua li cas kom ua tiav qhov ua haujlwm dawb muaj zog dua, lub teeb Glabridin muab peb txoj hauv kev sib txawv.
1. Kev tiv thaiv ntawm tyrosinase kev ua ub no
Lub mechanism tseem ceeb ntawm kev ua kom dawb ntawm cov plaub hauGlabridinyog los tiv thaiv kev tsim cov melanin los ntawm kev sib tw inhibiting tyrosinase kev ua ub no, tshem tawm ib feem ntawm tyrosinase los ntawm lub nplhaib catalytic ntawm melanin synthesis thiab tiv thaiv kev khi ntawm substrate rau tyrosinase.
2. Cov nyhuv antioxidant
Nws tuaj yeem tiv thaiv ob qho kev ua haujlwm ntawm tyrosinase thiab dopa pigment interchange thiab kev ua haujlwm ntawm dihydroxyindole carboxylic acid oxidase.
Nws tau pom tias ntawm qhov concentration ntawm 0.1mg / ml, photoglycyrrhizidine tuaj yeem ua rau cytochrome P450 / NADOH oxidation system thiab scavenge 67% ntawm cov dawb radicals, uas muaj cov tshuaj antioxidant muaj zog.
3. Tiv thaiv cov yam ntxwv inflammatory thiab tawm tsam UV
Tam sim no, muaj tsawg dua kev tshawb fawb tau tshaj tawm txog kev siv photoglycyrrhizidine hauv kev kawm txog kev laus ntawm daim tawv nqaij uas tshwm sim los ntawm UV. Xyoo 2021, hauv ib tsab xov xwm hauv phau ntawv xov xwm tseem ceeb Journal of Microbiology and Biotechnology, photoglycyrrhizidine liposomes tau kawm txog lawv lub peev xwm los kho qhov teeb meem erythema thiab kab mob ntawm daim tawv nqaij los ntawm kev txwv tsis pub muaj cov yam ntxwv inflammatory. Photoglycyrrhizidine liposomes tuaj yeem siv los txhim kho bioavailability nrog tsawg dua cytotoxicity nrog rau kev txwv tsis pub melanin zoo dua, txo qhov kev qhia tawm ntawm cov cytokines inflammatory, interleukin 6 thiab interleukin 10. Yog li ntawd, nws tuaj yeem siv ua tus neeg sawv cev kho mob sab nraud los tiv thaiv kev puas tsuaj ntawm daim tawv nqaij los ntawm UV los ntawm kev txwv tsis pub muaj kev o, uas yuav muab qee lub tswv yim rau kev tshawb fawb ntawm cov khoom tiv thaiv dawb ntawm lub hnub.
Hauv kev xaus, qhov ua kom dawb ntawm photoglycyrrhizidine tau lees paub, tab sis nws tus kheej xwm tsis yaj hauv dej, yog li nws tshwj xeeb tshaj yog xav tau rau kev tsim khoom thiab kev tsim khoom hauv kev siv cov khoom siv saib xyuas tawv nqaij ntxiv, thiab tam sim no nws yog qhov kev daws teeb meem zoo los ntawm kev siv tshuab liposome encapsulation. Ntxiv mus, duabGlabridinliposomes tuaj yeem tiv thaiv kev laus ntawm daim tawv nqaij los ntawm UV, tab sis qhov kev ua haujlwm no xav tau ntau qhov kev sim tshuaj kom paub tseeb thiab kev tshawb fawb kom siv tau.
Cov khoom siv saib xyuas tawv nqaij uas muaj photoGlabridin nyob rau hauv daim ntawv ntawm cov khoom xyaw sib xyaw.
Txawm hais tias tsis muaj qhov tsis ntseeg tias photoGlabridine muaj cov txiaj ntsig zoo heev rau kev ua kom dawb, nws cov nqi raw khoom kuj tsis tshua muaj vim muaj teeb meem hauv kev rho tawm thiab cov ntsiab lus. Hauv kev tshawb fawb txog kev kho kom zoo nkauj, kev ua haujlwm ntawm kev tswj tus nqi yog txuas ncaj qha rau cov ntsiab lus thev naus laus zis thiab cov txheej txheem kev tshawb fawb. Yog li ntawd, nws yog ib txoj hauv kev zoo los tswj tus nqi ntawm cov qauv thiab kom ua tiav qhov zoo thiab muaj txiaj ntsig zoo los ntawm kev xaiv cov khoom xyaw nquag thiab sib xyaw ua ke nrog photoglycyrrhizidine. Ntxiv rau ntawm qib R&D, kev tshawb nrhiav ntxiv yog qhov xav tau txog kev tshawb fawb ntawm photoglycyrrhizidine liposomes thiab cov txheej txheem rho tawm tshiab.
Lub sijhawm tshaj tawm: Lub Yim Hli-30-2022