Yog ihyrocoumarin lom

Dihydrocoumarin, cov tshuaj tsw qab, siv nyob rau hauv cov zaub mov, kuj siv ua coumarin hloov, siv ua kom hniav zoo nkauj; Muab cov cream, txiv maj phaub, cinnamon tsw; Nws tseem raug siv los ua kev luam yeeb tsw.

Yog ihyrocoumarin lom

Dihydrocoumarin tsis yog tshuaj lom. Dihydrocoumarin yog cov khoom lag luam uas pom hauv cov phaw hauv phaw vaninoceros. Nws tau npaj los ntawm hydrogenation ntawm coumarin nyob rau hauv muaj Nickel catalyst ntawm 160-200 ℃ thiab hauv qab siab. Nws kuj tseem siv tau los ua cov khoom siv raw, hydrolyzed hauv alkaline aqueous daws los tsim o-hydroxyphenyfproporionic acid, lub cev qhuav dej, kaw-voj tau.

Chaw Cia Khoom

Kaw thiab tsaus, khaws cia rau hauv qhov chaw txias thiab qhuav, qhov chaw nyob hauv lub thoob yog me me li sai tau thaum muaj kev tiv thaiv kev nyab xeeb, thiab muaj kev tiv thaiv nitrogen. Khaws rau hauv qhov chaw txias, tshuab ua kom muaj zog. Txav deb ntawm hluav taws, dej. Yuav tsum tau muab khaws cia cais tawm ntawm oxidizer, tsis txhob muab cov khoom sib xyaw. Nruab nrog cov sib raug zoo thiab ntau ntau ntawm cov khoom siv hluav taws.

Hauv kev kawm vitro

Nyob rau hauv vitro enzymatic assay, Dihydrocoumarin inducation-concentration-repend inhibition ntawm sft1 (ic50 ntawm 208μm). Txo hauv Sirt1 Deacetylase kev ua si tau pom txawm nyob ntawm Micromolar Doses (85 ± 5.8 thiab 73 ± 13.7% kev ua haujlwm ntawm 1.64, ntsig txog). MicroTubule Sirt2 Deacetylase tseem muaj kev tiv thaiv nyob rau hauv ib qho koob tshuaj zoo sib xws (IC50 ntawm 2954M).

Tom qab 24 teev ntawm kev kis, tiyrocoumarin (1-5mm) nce cytotoxicity hauv tk6 cell ntawm cov nqi-siab. Dihydrocoumarin (1-5mm) nce qhov mob apoptosis hauv tk6 cell ntawm kab hauv ib tus nqi-teev taw tes nyob rau 6 teev teev sijhawm. A 5 hli koob tshuaj li ntawm Dihydrocoumarin nce qhov mob apoptosis thaum 6 teev teev sijhawm hauv TK6 kab. Tom qab 24 teev tas lub sijhawm, DIHYDROCOUMARIN (1-5mm) nce puv puv PC3 Lysine 373 thiab 382 acetylation nyob rau hauv ib koob-delent kab.