Dihydrocoumarin, tshuaj tsw qab, siv hauv cov khoom noj, kuj siv los ua coumarin hloov, siv los ua kom zoo nkauj tsw; Sib tov qaub cream, txiv maj phaub, cinnamon tsw; Nws kuj yog siv los ua luam yeeb tsw.
Yog dihydrocoumarin tshuaj lom
Dihydrocoumarin tsis muaj tshuaj lom. Dihydrocoumarin yog ib yam khoom ntuj pom nyob rau hauv daj vanilla rhinoceros. Nws yog npaj los ntawm hydrogenation ntawm coumarin nyob rau hauv lub xub ntiag ntawm nickel catalyst ntawm 160-200 ℃ thiab nyob rau hauv siab. Nws tseem tuaj yeem siv los ua cov khoom siv raw, hydrolyzed hauv alkaline aqueous tov los tsim o-hydroxyphenylpropionic acid, lub cev qhuav dej, kaw-voj tau.
Kev cia khoom
Kaw thiab tsaus, khaws cia rau hauv qhov chaw txias thiab qhuav, qhov chaw hauv lub thoob yog me me raws li qhov ua tau raws li kev tso cai kev nyab xeeb, thiab muaj kev tiv thaiv nitrogen. Khaws rau hauv ib qho chaw txias, ventilated warehouse. Nyob deb ntawm hluav taws, dej. Yuav tsum tau muab cais los ntawm oxidizer, tsis txhob sib tov cia. Nruab nrog cov khoom sib xws thiab qhov ntau ntawm cov khoom siv hluav taws xob.
Kev tshawb fawb hauv vitro
Hauv vitro enzymatic assay, dihydrocoumarin induced concentration-dependent inhibition ntawm SIRT1 (IC50 ntawm 208μM). Kev txo qis hauv SIRT1 deacetylase kev ua haujlwm tau pom txawm tias ntawm micromolar koob tshuaj (85 ± 5.8 thiab 73 ± 13.7% kev ua haujlwm ntawm 1.6μM thiab 8μM, feem). Microtubule SIRT2 deacetylase kuj tau inhibited nyob rau hauv ib qho zoo sib xws koob tshuaj raws li (IC50 ntawm 295μM).
Tom qab 24 teev ntawm kev raug, dihydrocoumarin (1-5mM) nce cytotoxicity hauv TK6 cell kab nyob rau hauv ib koob tshuaj. Dihydrocoumarin (1-5mM) nce apoptosis hauv TK6 cell kab nyob rau hauv ib koob tshuaj ntawm 6-teev sij hawm taw tes. Ib koob tshuaj 5mM ntawm dihydrocoumarin nce apoptosis ntawm 6-teev lub sijhawm taw qhia hauv TK6 kab ntawm tes. Tom qab lub sij hawm raug 24-teev, dihydrocoumarin (1-5mM) nce p53 lysine 373 thiab 382 acetylation nyob rau hauv ib koob tshuaj nyob rau hauv TK6 cell kab.
Post lub sij hawm: Nov-01-2024