Chlorphenesin

Chlorphenesin(104-29-0), lub npe tshuaj yog 3-(4-chlorophenoxy)propane-1,2-diol, feem ntau yog synthesized los ntawm cov tshuaj tiv thaiv ntawm p-chlorophenol nrog propylene oxide lossis epichlorohydrin. Nws yog ib qho tshuaj tua kab mob thiab tshuaj tua kab mob dav dav, uas muaj cov nyhuv antiseptic rau cov kab mob Gram-positive, cov kab mob Gram-negative, yeasts thiab pwm. Nws tau txais kev pom zoo rau kev siv hauv cov tshuaj pleev ib ce los ntawm ntau lub tebchaws thiab thaj chaw xws li Tebchaws Europe, Tebchaws Meskas, Nyiv Pooj, thiab Tuam Tshoj. Qhov txwv tsis pub siv uas tau pom zoo los ntawm feem ntau cov kev cai lij choj hauv tebchaws thiab cov cai yog 0.3%.
Chlorphenesinthawj zaug tsis tau siv ua tshuaj tiv thaiv, tab sis ua ib qho tshuaj tiv thaiv kab mob uas cuam tshuam nrog antigen uas tiv thaiv IgE-mediated histamine tso tawm hauv kev lag luam tshuaj. Hais yooj yim, nws yog anti-allergic. Thaum ntxov li xyoo 1967, kev lag luam tshuaj tau kawm txog kev siv chlorphenesin thiab penicillin los tiv thaiv kev ua xua los ntawm penicillin. Nws tsis yog txog xyoo 1997 uas chlorphenesin tau tshawb pom los ntawm Fabkis rau nws cov tshuaj tua kab mob thiab cov kab mob bacteriostatic thiab thov rau cov ntawv pov thawj cuam tshuam.
1. Puas yog chlorphenesin ua rau cov leeg nqaij so?
Daim ntawv ntsuam xyuas tau qhia meej meej tias: cov khoom xyaw chlorphenesin hauv kev pleev kom zoo nkauj tsis muaj cov nyhuv uas ua rau cov leeg nqaij tsis muaj zog. Thiab nws tau hais ntau zaus hauv daim ntawv qhia: Txawm hais tias cov lus luv luv lus Askiv ntawm cov khoom xyaw tshuaj chlorphenesin thiab cov khoom xyaw pleev kom zoo nkauj chlorphenesin yog Chlorphenesin, ob qho tib si yuav tsum tsis txhob tsis meej pem.
2. Cov tshuaj chlorphenesin puas ua rau daim tawv nqaij khaus?
Txawm yog tib neeg lossis tsiaj txhu los xij, chlorphenesin tsis ua rau tawv nqaij khaus ntawm qhov concentration ib txwm muaj, thiab nws tsis yog ib qho ua rau tawv nqaij khaus lossis ua rau lub teeb ci ntsa iab. Tsuas muaj plaub lossis tsib tsab xov xwm txog cov lus ceeb toom ntawm chlorphenesin ua rau tawv nqaij o. Thiab muaj ob peb qhov xwm txheej uas chlorphenesin siv yog 0.5% txog 1%, ntau dua li qhov concentration siv hauv cov tshuaj pleev ib ce. Hauv ntau lwm qhov xwm txheej, nws tsuas yog hais tias chlorphenesin muaj nyob rau hauv cov mis, thiab tsis muaj pov thawj ncaj qha tias chlorphenesin ua rau mob dermatitis. Xav txog qhov siv loj ntawm chlorphenesin hauv cov tshuaj pleev ib ce, qhov tshwm sim no yeej tsis tseem ceeb.
3. Cov tshuaj chlorphenesin puas yuav nkag mus rau hauv cov ntshav?
Cov kev sim tsiaj tau qhia tias qee cov chlorphenesin yuav nkag mus rau hauv cov ntshav tom qab nws kov daim tawv nqaij. Feem ntau ntawm cov chlorphenesin uas nqus tau yuav raug metabolized hauv cov zis, thiab tag nrho nws yuav raug tso tawm ntawm lub cev hauv 96 teev. Tab sis tag nrho cov txheej txheem yuav tsis tsim cov kev phiv tshuaj lom.
4. Chlorphenescine puas yuav txo qhov kev tiv thaiv kab mob?
Yuav tsis ua li ntawd. Chlorphenesin yog ib yam tshuaj uas tiv thaiv kab mob uas cuam tshuam nrog cov antigen uas rov qab tau. Ua ntej tshaj plaws, chlorphenesin tsuas yog ua lub luag haujlwm tseem ceeb thaum muab sib xyaw nrog cov antigen uas tau teev tseg, thiab nws tsis txo qhov kev tiv thaiv kab mob ntawm lub cev, thiab nws tsis ua rau tus kab mob kis tau ntau ntxiv. Qhov thib ob, tom qab tsis siv lawm, cov nyhuv tiv thaiv kab mob ntawm cov antigen uas tau teev tseg yuav ploj mus, thiab yuav tsis muaj txiaj ntsig mus tas li.
5. Qhov xaus lus kawg ntawm kev ntsuam xyuas kev nyab xeeb yog dab tsi?
Raws li cov ntawv thov thiab kev siv uas twb muaj lawm hauv Tebchaws Meskas (ntxuav tawm 0.32%, hom neeg nyob hauv 0.30%), FDA ntseeg tiastshuaj chlorphenesinmuaj kev nyab xeeb ua ib qho tshuaj preservative rau cov khoom kom zoo nkauj.