α-arbutinthiab β-arbutin yog ob hom tshuaj sib txuas uas feem ntau siv rau hauv cov khoom siv rau kev saib xyuas tawv nqaij kom lawv cov teebmeem ua rau tawv nqaij dawb thiab ci ntsa iab. Txawm hais tias lawv muaj cov qauv tseem ceeb thiab cov txheej txheem ua haujlwm zoo sib xws, muaj qhov sib txawv me ntsis ntawm ob qho no uas tuaj yeem cuam tshuam rau lawv cov txiaj ntsig thiab cov kev mob tshwm sim.
Nyob rau hauv cov qauv, ob qho tib si α-arbutin thiab β-arbutin yog glycosides ntawm hydroquinone, uas txhais tau tias lawv muaj ib tug glucose molecule txuas rau ib tug hydroquinone molecule. Qhov kev zoo sib xws ntawm cov qauv no tso cai rau ob qho tib si tshuaj kom inhibit lub enzyme tyrosinase, uas yog koom nrog rau hauv melanin ntau lawm. Los ntawm kev inhibiting tyrosinase, cov tshuaj no tuaj yeem pab txo qhov kev tsim ntawm melanin, ua rau lub ntsej muag sib dua thiab sib npaug dua.
Qhov sib txawv tseem ceeb ntawm α-arbutin thiab β-arbutin nyob rau hauv qhov chaw ntawm glycosidic daim ntawv cog lus ntawm cov piam thaj thiab hydroquinone moieties:
α-arbutin: Hauv α-arbutin, cov glycosidic bond raug txuas rau ntawm qhov chaw alpha ntawm lub nplhaib hydroquinone. Qhov kev tso cai no ntseeg tau tias yuav txhim kho qhov ruaj khov thiab solubility ntawm α-arbutin, ua rau nws zoo dua rau kev siv rau ntawm daim tawv nqaij. Cov glycosidic bond kuj txo qhov muaj peev xwm rau oxidation ntawm hydroquinone, uas tuaj yeem ua rau muaj cov tshuaj tsaus nti uas tawm tsam qhov cuam tshuam ntawm daim tawv nqaij.
β-arbutin: Hauv β-arbutin, qhov glycosidic bond txuas rau ntawm qhov chaw beta ntawm lub nplhaib hydroquinone. Thaum β-arbutin kuj tseem ua haujlwm zoo hauv kev txwv tsis pub tyrosinase, nws yuav tsis ruaj khov dua li α-arbutin thiab yooj yim rau oxidation. Qhov oxidation no tuaj yeem ua rau muaj cov tshuaj xim av uas tsis xav tau rau kev ua kom tawv nqaij dawb.
Vim nws ruaj khov thiab yaj tau zoo dua, α-arbutin feem ntau suav hais tias yog daim ntawv zoo dua thiab nyiam siv rau kev siv rau kev saib xyuas tawv nqaij. Nws ntseeg tau tias yuav ua rau daim tawv nqaij dawb dua thiab yuav tsis ua rau muaj kev hloov pauv xim lossis cov kev mob tshwm sim tsis xav tau.
Thaum xav txog cov khoom siv rau kev saib xyuas tawv nqaij uas muajarbutin, nws yog ib qho tseem ceeb uas yuav tsum nyeem daim ntawv lo ntawm cov khoom xyaw kom paub seb puas siv α-arbutin lossis β-arbutin. Txawm hais tias ob qho tshuaj no tuaj yeem ua haujlwm tau zoo, α-arbutin feem ntau suav tias yog qhov kev xaiv zoo dua vim nws qhov ruaj khov thiab muaj zog dua.
Nws tseem ceeb heev uas yuav tsum nco ntsoov tias qhov kev ua xua ntawm daim tawv nqaij ntawm ib tus neeg yuav txawv. Qee tus neeg yuav muaj kev phiv xws li khaus lossis liab ntawm daim tawv nqaij thaum siv cov khoom uas muaj arbutin. Ib yam li lwm yam khoom xyaw rau kev saib xyuas tawv nqaij, nws raug nquahu kom ua qhov kev sim ua ntej siv cov khoom no rau thaj chaw loj dua ntawm daim tawv nqaij thiab sab laj nrog kws kho mob tawv nqaij yog tias koj muaj kev txhawj xeeb txog kev ua xua.
Xaus lus, ob qho tib si α-arbutin thiab β-arbutin yog glycosides ntawm hydroquinone siv rau lawv cov teebmeem ua kom tawv nqaij dawb. Txawm li cas los xij, α-arbutin qhov chaw ntawm glycosidic bond ntawm qhov chaw alpha ua rau nws ruaj khov thiab solubility ntau dua, ua rau nws yog qhov kev xaiv nyiam dua rau cov khoom siv saib xyuas tawv nqaij uas tsom mus rau kev txo cov hyperpigmentation thiab ua tiav cov tawv nqaij sib npaug dua.
Lub sijhawm tshaj tawm: Lub Yim Hli-30-2023